Perfect Glycemic Meal – Vanilla Delight

Description

InSea² is a clinically tested blend of purified polyphenols sourced from Ascophyllum nodosum and Fucus vesiculosus, two species of wild-crafted brown seaweed. It is the only product on the market that targets enzymes involved in carbohydrate digestion and assimilation with a dual mechanism of action. InSea² inhibits alpha-amylase (a starch-degrading enzyme) and alpha-glucosidase (a sucrose-degrading enzyme) and reduces the after-meal impact of ingested high-glycemic–index foods. In humans, InSea² (500 mg/d) attenuated by 48% the rise in blood glucose normally produced by ingesting white bread, reduced insulin secretion by 12%, and improved insulin sensitivity by 8% compared to placebo.[1] Lowering postprandial blood glucose may support glucose/insulin regulation, improve insulin sensitivity, and support healthy lipid profiles, leptin levels, and appetite control. In another human trial, treatment with a formulation containing InSea² resulted in a 33% increase in feelings of satiety, a decrease in next-meal caloric intake, and a significant impact on weight reduction compared to placebo.[2] InSea² has been evaluated in clinical trials, animal safety and efficacy studies, and in vitro tests. It has an excellent safety profile and is friendly to the gastrointestinal tract.*

CinSulin® is a clinically proven, patented water extract of cinnamon (Cinnamomum cassia) shown to influence glucose metabolism. The unique proprietary extraction and dehydration process for manufacturing CinSulin results in a concentrated (10:1) extract that minimizes undesirable substances while retaining those substances that are health-promoting, such as type-A polyphenolic polymers. Cinnamon has been studied extensively for its roles in glucose uptake, glycogen synthesis, insulin action, and support for healthy blood lipid metabolism.[3,4] Anderson et al demonstrated a 20-fold increase in glucose uptake in fat cells treated with water-soluble type-A polymers.[5] In human studies, water-extracted cinnamon supplementation (500 mg/d) helped the body maintain healthy blood sugar levels,[6] improved antioxidant status,[7] and supported healthy blood pressure and body composition changes.*[4]

Vegan Protein Blend is a pure, sweetener-free, vegetable protein blend sourced from non-GMO pea protein concentrate, pea protein isolate, and rice protein concentrate. This proprietary blend achieves an amino acid score of 100% and has excellent digestibility. Moderately high-protein, low-glycemic foods help increase feelings of satiety and support healthy body composition, healthy blood lipid metabolism, and postprandial glucose levels.[8-10] In an animal study comparing the effects of pea protein and casein on blood lipids, rats fed pea proteins showed a significant improvement in blood lipid levels compared to rats that were fed casein. The researchers also found that the pea proteins appeared to “affect cellular lipid homeostasis by upregulating genes involved in hepatic cholesterol uptake and by downregulating fatty acid synthesis genes.”[10] These findings were echoed in a 2013 study performed in rats that tested the effects of a combination of pea protein and soluble fibers on cholesterol homeostasis and metabolism.*[11]

Inulin, a soluble fiber from chicory root, is utilized in the Perfect Glycemic Meal formulas (8 g/serving) as a low-glycemic–index carbohydrate that supports glucose management and gastrointestinal health. In a randomized, triple-blind, controlled trial, 49 females received either 10 g/d of inulin (intervention, n = 24) or maltodextrin (control, n = 25) for two months. At the end of the study period, significant positive effects were recorded on several glycemic and antioxidant indices (e.g., glucose metabolism, glycosylated hemoglobin, malondialdehyde, and total antioxidant capacity) in the inulin group when compared to the maltodextrin group (P < 0.05).[12] As a prebiotic, inulin promotes the growth of beneficial intestinal bacteria.*

Benfotiamine is a lipid-soluble, highly bioavailable form of thiamin (vitamin B1) that enhances the activity of transketolase, an enzyme that catalyzes the conversion of harmful glucose intermediate metabolites in the pentose phosphate pathway.[13] In vitro research showed treatment with benfotiamine had an impressive effect on transketolase activity (454% increase from control). Researchers further demonstrated that increasing transketolase activity diverts harmful intermediate metabolites away from three of the major pathways (including advanced glycation end-product formation) implicated in hyperglycemia-induced vascular damage.[14] In addition to benfotiamine, Perfect Glycemic Meal provides a full spectrum of highly bioavailable B vitamins, including folate, as Quatrefolic, and high-dose biotin to support carbohydrate/glucose metabolism, insulin action, and nerve health.*

Alpha-Lipoic Acid (ALA) and Green Tea Leaf Extract is included in Perfect Glycemic Meal for it’s well-known protective antioxidant effects as well as for their roles in glucose metabolism and insulin action and sensitivity.[15,16] Additionally, green tea leaf extract has been shown to support a healthy body mass index, and ALA has important roles in protecting peripheral nerves.[17] AMP-activated protein kinase (AMPK) and adiponectin, an adipokine, are targets of cardiometabolic health research due to their roles in cellular energy homeostasis and insulin sensitizing, respectively. The effects of ALA on these targets were studied in rats fed a high-fat or low-fat (control) diet. The researchers found ALA supplementation reduced body weight and adiposity in both groups. In the high-fat diet group, ALA supported insulin homeostasis and stimulated AMPK and adiponectin in white adipose tissue.*[18]

Chromium, Vanadium, and Zinc are provided as Albion® TRAACS® amino acid chelates for optimal absorption and utilization. Chromium supports the metabolic action of insulin and may work synergistically with biotin to improve glucose tolerance. Vanadium may reduce hepatic gluconeogenesis and mimic insulin’s effect while zinc plays a major role in the stabilization of insulin hexamers and the pancreatic storage of the hormone.*