Painex

Description

Clinical Applications

• ​Supports Healthy Cytokine Balance and the Body’s Normal Response to Inflammation
• Relief for Joint Discomfort
• Contains 40 mg Proprietary Bioflavonoid Berry Blend
• Supports Antioxidant Mechanisms

Dr. Q’s PainEx is formulated to support the body’s normal response to inflammation and provide relief for joint discomfort. 5-LOXIN ® , a patented Boswellia extract yielding concentrated 3-O-acetyl-11-keto-ß-boswellic acid (AKBA), is found to inhibit the 5-lipoxygenase enzyme. Salicin from white willow bark is a natural inhibitor of both the COX-2 and 5-lipoxygenase enzymes. Bioflavonoid-rich BerryVin TM provides additional support for cytokine balance and antioxidant activity.

Discussion

White Willow Bark (Salix alba) Willow bark has been used for thousands of years to support the body’s normal response to inflammation and to help relieve discomfort. [1-3] Willow bark is currently approved by the German Commission E and the European Scientific Cooperative on Phytotherapy (ESCOP) for these purposes. Willow bark is also recognized in the United States for its effectiveness in the relief of joint discomfort. [1] Willow bark contains glycosides, salicylates, flavonoids, tannins, aromatic compounds, and acids. A 2007 systemic review of the literature discussing the effect of salicin (one of the salicylates found in white willow bark) on the body’s normal response to inflammation found moderate evidence to support a short-term cytokine-balancing effect when daily doses were standardized to 120-240 mg salicin. Dr. Q’s PainEx provides a standardized 120 mg dose of salicin per serving.​

Various randomized, placebo-controlled studies suggest that willow bark produces positive effects on joint discomfort that are sometimes similar to those of aspirin (acetylsalicylic acid); the usual dose of salicin is 240 mg per day. [5] Pharmacokinetic evaluations reveal that salicylic acid is the major metabolite of salicin, though other components of willow bark are believed to have analgesic effects as well.

5•Loxin ® , a standardized Boswellia serrata extract enriched to 30% 3-O-acetyl-11-keto-ß-boswellic acid (AKBA), is ten times more concentrated than ordinary B serrata. Boswellia serrata is an ayurvedic herb whose principle constituents—boswellic acid and alpha-boswellic acid—may help maintain healthy leukotriene metabolism by reducing the activity of the enzyme 5-lipoxygenase. [7] 5-lipoxygenase (5-LOX) catalyzes the synthesis of proinflammatory leukotrienes.

A randomized, double-blind, placebo-controlled trial assessing the efficacy, safety, and tolerability of Boswellia extract produced statistically significant and clinically relevant decreases in knee discomfort, increases in knee flexion, and increases in walking distance. [8] A randomized, double-blind, placebo-controlled study specifically designed with 5•Loxin resulted in statistically significant improvements in “pain scores and physical function” as well as a significant reduction in matrix metalloproteinase (MMP) in synovial fluid. [9] MMP represents a class of enzymes that selectively hydrolyze peptide bonds and degrade structural proteins; they play a crucial role in the degradation of joint tissues. 5•Loxin shows significant inhibition against several MMPs. It helps prevent the formation of human recombinant TNF-α inducible MMPs, which further facilitates the maintenance of healthy cartilage and cell-cycle regulation.

BerryVin TM (40 mg) contains a blend of blueberries, strawberries, escobillo, and cranberries, along with grape and pomegranate extracts. This bioflavonoid-rich berry powder provides polyphenols, anthocyanins, ellagic acid, and an antioxidant capacity of 4000 TE/g to fight free radicals. It may also provide substantial antioxidant support for soft tissues. Bioflavonoids are thought to act synergistically to inhibit cyclooxygenases, lipoxygenases, and phospholipases, ultimately supporting the body’s normal response to inflammation.

Directions

Take two capsules twice daily, or as directed by your healthcare practitioner. Children, pregnant or lactating women, and individuals using blood thinners should consult their healthcare practitioner prior to use. Do not use if tamper seal is damaged.

Cautions
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Wheat, gluten, corn protein, yeast, soy, animal or dairy products, fish, shellfish, peanuts, tree nuts, egg, artificial colors, artificial sweeteners, or preservatives.